News & Events
This page contains news and upcoming events that MRC-Holland will attend.

▷ Reduced sloping with the new MLPA buffer
Starting March 2019, all shipments of SALSA MLPA Reagent Kits will include a modified SALSA MLPA Buffer. There will also be a small change in the storage buffer of the SALSA Ligase-65 enzyme. The new reagents strongly reduce peak pattern sloping that is frequently observed when DNA is extracted with a magnetic beads-based system. If you did not have this issue, the new reagents will not affect your results.

If you previously had sloping caused by a magnetic bead-based DNA extraction method and used the S4 Sample Stabiliser to improve your results, you most likely do not need to add the S4 Sample Stabiliser anymore. The new reagents will not eliminate other causes of sloping.

More information on the background of this change, its effects, the timeline and our validation study can be found on this page.

▷ Launch of SALSA Melt Assay: SALSA MC002 SMA Newborn Screen
The SALSA MC002 SMA Newborn Screen is the latest product from MRC Holland, and the only product targeted at newborn population screening for a disorder. The assay is simple to use and runs on standard equipment allowing easy implementation and streamlining SMA screening. For more information visit our launch page, or see our press release.

▷ MRC-Holland to supply HhaI enzyme
Important news for MS-MLPA users: MRC-Holland has launched its own restriction enzyme SALSA HhaI. The HhaI enzyme – an essential component of MS-MLPA reactions – was developed to ensure that every aspect of MLPA, from start to result interpretation, is of the highest standards.

A free vial of SALSA HhaI enzyme (item number: SMR51) will be included with all orders containing an MS-MLPA probemix from 3 April until 31 December 2018 (extended). More information can be found here.

Come and Meet Us
If you are attending one of the following meetings, please stop by our booth to learn more about how MRC-Holland's products can be used to benefit your DNA or methylation analysis.

  • 15–18 JuneESHG 2019, Gothenburg, Sweden (booth #548).

MRC-Holland booth at a congress
The upcoming MLPA workshops organised by MRC-Holland are listed on our Support Portal.
Improved Products
P090-BRCA2
Breast and ovarian cancer, hereditary (HBOC)
P239-BRCA1 region
Breast cancer
P188-22q13
Phelan-Mcdermid syndrome
P045-BRCA2/CHEK2
Breast and ovarian cancer, hereditary (HBOC); Susceptibility to breast cancer; Susceptibility to other cancer types
P315-EGFR
Tumours, solid
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