Complete Probemix List
Below is the complete overview of all SALSA MLPA probemixes offered by MRC-Holland. You can sort products by article number or application. Please note you can also use the search function above to find a specific gene or application.

Product NameApplicationRegion
A054-Campylobacter MBiT mix 1basic research to be discontinued - Genotyping of Campylobacter jejuni isolates Campylobacter
A055-Campylobacter MBiT mix 2basic research to be discontinued - Genotyping of Campylobacter jejuni isolates Campylobacter
ME001-Tumour suppressor mix 1basic research Tumour suppressor genes Various
ME002-Tumour suppressor mix 2basic research Tumour suppressor genes Various
ME011-MMR Mismatch repair genes (MMR) MLH1 3p22.2; MSH2 2p21; MSH6 2p16.3; PMS2 7p22.1; EPCAM 2p21; BRAF V600E
ME012-MGMT-IDH1-IDH2 Gliomas MGMT, IDH1, IDH2
ME024-9p21 Tumours, Cutaneous melanoma 9p21: CDKN2A, CDKN2B, and flanking genes
ME028-PWS/AS Prader-Willi syndrome (PWS); Angelman syndrome (AS) PWS/AS region (15q11-13), MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, OCA2
ME029-FMR1/AFF2 Fragile X FMR1, AFF2
ME030-BWS/RSS Beckwith-Wiedemann syndrome (BWS); Russell-Silver syndrome (RSS) 11p15 region, H19, IGF2, CDKN1C, KCNQ1
ME031-GNAS Albright hereditary osteodystrophy (AHO), Pseudohypoparathyroidism (PHP) GNAS 20q13.32
ME032-UPD7-UPD14 Uniparental disomy 7 (UPD7); Russel-Silver syndrome (RSS); Uniparental disomy 14 (UPD14); Temple syndrome (TS); Kagami-Ogata syndrome (KOS) Chr. 6q24; 7p12; 7q32; 14q32
ME033-TNDM Transient neonatal diabetes mellitus Chr. 6q24; 11p15
ME034-Multi-locus Imprinting Multi-locus imprinting defects; To distinguish maternal and paternal triploidies 6q24.2; 7q32.2; 11p15.5; 14q32.2; 15q11.2; 19q13.43; 20q13.32 imprinted regions
ME042-CIMPbasic research CpG Island methylator phenotype (CIMP) Various
P002-BRCA1CE;CO;MA;IL Breast and ovarian cancer, hereditary (HBOC) BRCA1 17q21.31
P003-MLH1/MSH2CE;MA;IL Lynch syndrome MLH1 3p22.2; MSH2 2p21
P008-PMS2CE;IL Lynch syndrome; Constitutional MMR-deficiency syndrome (CMMR-D) PMS2 7p22.1
P010-POLG Mitochondrial maintenance POLG 15q26.1; POLG2 17q23.3; TWNK (C10orf2) 10q24.31; SLC25A4 (ANT1) 4q35.1
P011-VWF mix 1 Von Willebrand disease (vWD) VWF 12p13.31
P012-VWF mix 2 Von Willebrand disease (vWD) VWF 12p13.31
P013-ATRX Alpha-thalassemia X-linked intellectual disability syndrome (ATRX) ATRX Xq21.1
P014-Chromosome 8 Tumour research Chr. 8
P015-MECP2CE;IL RETT syndrome, classic; RETT syndrome, atypical; MECP2 duplication syndrome; X-linked intellectual disability syndrome MECP2 Xq28; CDKL5 Xp22.13; ARX Xp21.3; NTNG1 1p13.3
P016-VHLCE;MA;IL Von Hippel-Lindau syndrome VHL 3p25.3
P017-MEN1CE;IL Multiple endocrine neoplasia type 1 (MEN1) MEN1 11q13.1
P018-SHOXCE;CO;IL Leri-Weill dyschondrosteosis (LWD); Langer mesomelic dysplasia (LMD); Idiopathic short stature (ISS) SHOX Xp22.33/Yp11.32
P021-SMACE;MA;IL Spinal muscular atrophy (SMA) SMN1 5q13.2; SMN2 5q13.2
P022 -PLP1 Pelizaeus-Merzbacher disease (PMD); Spastic paraplegia type 2 (SPG2) PLP1 Xq22.2
P025-Canavan Canavan disease ASPA 17p13
P026-Sotos Sotos syndrome NSD1 5q35; NFIX 19p13
P027-Uveal melanoma Uveal melanoma (UM) Chr. 1p, 3, 6, 8
P028-FHL Hemophagocytic lymphohistiocytosis, familial (FHL) type 2, 3, 4 UNC13D 17q25.1; PRF1 10q22.1; STX11 6q24.2
P029-WBS Williams-Beuren syndrome (WBS); 7q11.23 duplication syndrome WBS criticial region 7q11.23
P031-FANCA mix 1 Fanconi anemia (FA) FANCA 16q24.3
P032-FANCA mix 2 Fanconi anemia (FA) FANCA 16q24.3
P033-CMT1CE;MA;IL Charcot-Marie-Tooth neuropathy (CMT); Neuropathy with liability to pressure palsies, hereditary (HNPP) CMT/HNPP region 17p12; KIF1b 1p36
P034-DMD-1CE;CO;MA;IL Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD) DMD Xp21.1-p21.2
P035-DMD-2CE;CO;MA;IL Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD) DMD Xp21.1-p21.2
P036-Subtelomeres Mix 1CE;MA;IL Subtelomeric testing All subtelomeres
P037-CLL-1 Chronic lymphocytic leukemia (CLL) Various
P038-CLL-2 Chronic lymphocytic leukemia (CLL) Various
P040-CLL Chronic lymphocytic leukemia (CLL) Various
P041-ATM-1CE;MA;IL Ataxia-telangiectasia (AT); Predisposition to develop cancer, hereditary ATM 11q22.3
P042-ATM-2CE;MA;IL Ataxia-telangiectasia (AT); Predisposition to develop cancer, hereditary ATM 11q22.3
P043-APCCE;MA;IL Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1) APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
P044-NF2CE;improved Neurofibromatosis type 2 (NF2) NF2 22q12.2
P045-BRCA2/CHEK2CE;CO;MA;IL Breast and ovarian cancer, hereditary (HBOC); Susceptibility to breast cancer; Susceptibility to other cancer types BRCA2 13q13.1; CHEK2 22q12.1
P046-TSC2CE;improved Tuberous sclerosis complex (TSC) TSC2 16p13.3
P047-RB1 Retinoblastoma (RB) RB1 13q14.2
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